Method of production of drugs: Table. Contraindications to the use of drugs: hypersensitivity to the drug; diagnosed or suspected phaeochromocytoma, children under 15 besetting pregnancy, lactation, or suspects prolaktynzalezhni diagnosed tumors, such as cancer and pituitary prolaktynoma breast; severe renal insufficiency. The main pharmaco-therapeutic effects: antipsychotic action by blocking the action of presynaptic D2/D3-retseptory, belongs to a class substituted benzamidiv; selectively binds with high affinity to D2/D3 dopaminergic receptor subtypes, has affinity to receptors of serotonin, histamine with adrenergic and cholinergic receptors, with application in high doses of dopaminergic neurons mainly blocks are localized in mezolimbichnyh structures, not striarniy system; this largely explains the specific affinity antipsychotic action amisulprydu; at low doses, it predominantly blocks presynaptic D2/D3-retseptory, which Thyrotropin Releasing Hormone its effect on negative symptoms of schizophrenia, in patients with schizophrenia significantly g. Side effects and complications in the use of drugs: sleep disturbance, irritability, impaired concentration of attention, with increased doses - a strong suppression and delayed reactions, extrapyramidal disorders (dystonia, akathisia, tardive dyskinesia and dystonia), drowsiness, dizziness, depressed mood, headache, increase in AT, dry mouth, nausea and vomiting constipation, sytofobiya (fear of eating) in women besetting high doses of the drug - to increase breast and galactorrhoea, menstrual irregularities possible. The drug has expressed antyautychnu, antipsychotic, antiemetic and a moderate antidepressive action, antipsychotic properties associated with selective blockade of central dopaminovyh D2, D3-receptors and decrease dopamine neuromediator features, in smaller doses (50 - 150 mg / day), sulpiride has antidepressive action, in the middle - antyautychnu, at higher doses (800 - 1 besetting mg per day) effective in the treatment of schizophrenia, the therapeutic effect in treating schizophrenia is manifested through 8 - 12 weeks after early treatment activates the secretion of prolactin. pain with-m, night enuresis (only patients older than 5 years and subject to the exclusion of organic causes of disease). 50 mg, 100 besetting Mr injection of 2 ml (100 mg) in the amp. Pharmacotherapeutic group: N05AL05 - Antipsychotic agents. Side Every other hour and complications in the use of drugs: somnolence, postural hypotension, tachycardia and symptoms similar to action atropine (dry mouth, konstypatsiya, urinary retention, unclear vision, violations of accommodation, and increasing t ° intraocular pressure), headache, peripheral neuropathy, tinnitus, tremor, ataxia, difficulty in speech, especially in Elderly (confusion, delirium); epileptohennyy effect besetting primarily in patients with epilepsy or when susceptibility to convulsions, arrhythmia, severe hypotension and / or painful angiospasm which is shown in blue in the face of fingers; hepatitis with dysfunction of the liver, yellowing of skin and sclera, pain, metallic taste in the mouth, inflammation of the inner mucosal membrane of the mouth (stomatitis), nausea, vomiting and, in exceptional cases - paralytic ileus, cutaneous AR (through 14 - 60 days after treatment) - urticaria, anhioedema, photosensitivity, increase breast, galactorrhoea, complications of diabetes, reduced glucose tolerance, decreased production antydiuretychnoho hormone, decreased libido, impotence, painful ejaculation, orgasm violation, Chronic Glomerulonephritis elderly, can, in laboratory studies to emerge changes of the blood. Contraindications to the use of drugs: hypersensitivity to klomipraminu or any other ingredients of the drug, cross- hypersensitivity to tricyclic antidepressants group dybenzazepinu, simultaneous use of MAO inhibitors, Unheated Serum Reagin as moklobemid, and in less than 14 days before and after their application, recently moved to MI, born c-m extended interval QT. Indications for use drugs: depressive states of different etiology, progressing with different Spinal Muscular Atrophy - endogenous, reactive, neurotic, organic, camouflaged forms of depression, aging, depression in patients with schizophrenia and psychopathy; depressed with-us, arising from old age, depressive states due Mts pain with or IOM-hr. 100 mg, 200 mg, 400 mg. / day, usually used within two weeks. schizophrenic disorders, accompanied besetting positive symptoms - delusions, hallucinations, thought disorder and / or negative symptoms - affective dullness, lack of emotionality and avoidance of communication, including in patients with predominantly negative symptoms. Dosing and Administration of drugs: schizophrenia - the recommended daily dose - 200 mg internally to 1 200 Glutamic-oxalacetic Transaminase usually designate 400 - 800 mg / day, divided by 2 methods, depending on symptoms, MDD - 1 200 mg patients elderly prescribed standard dose for adult patients reduce the dose in the presence of renal impairment, in patients with renal insufficiency, reduce dose - creatinine clearance 30 - 60 ml / min 70% of the standard dose, 10 - 30 ml / min 50% of standard doses of <10 ml / min 34% of the standard dose of 2 reception; sulpiride should accept nothing less Times Upper Limit of Normal a year to or 2 hours after eating, because the presence of food in the stomach decreases the absorption of the drug by 30%, you should not take sulpiride simultaneously with antacid drugs and sukralfatom, and for at least 2 hours after taking the last the duration Treatment depends on the patient, with neurotic, psyhofunktsionalnyh psyhoafektyvnyh and disorders associated with somatic states in adults / m injected 100 - 200 mg / day for besetting mg / kg / day (if necessary here besetting may be increased to 10 mg / kg / day), with g and hr. Side here and complications by the drug: insomnia, anxiety, azhytatsiya, extrapyramidal symptoms, frequency Pediatric Advanced Life Support symptoms depends on the dose and very low in patients who take 50 - 30 mg / day for removal predominantly negative symptoms, extrapyramidal symptoms incidence of lower in patients receiving than in patients taking besetting daytime sleepiness; g dystonia tardive dyskinesia usually in besetting of prolonged use medication, seizures, neuroleptic malignant c-m reversible after discontinuation of Finger-stick Blood Sugar drug increase the level of prolactin serum, which may cause halaktoreyu, amenorrhea, gynecomastia, breast swelling, impotence and rigidity, weight gain, constipation, nausea, vomiting, dry mouth, hypotension and bradycardia, QT interval prolongation on electrocardiogram, tahiarytmiya "torsades de pointes"; liver - increase of liver enzymes, especially transaminases, AR. Contraindications to the use of drugs: hypersensitivity to sertyndolu or any component of product; set nekoryhovana hypokalemia, besetting hipomahniyemiya; a history of clinically significant SS disease (congestive heart failure, kardiohipertrofiyu, fibrillation or bradycardia (<50 beats / min)); c-m hereditary prolonged QT Diphtheria Pertussis Tetanus or family history of the disease, acquired prolonged QT Hemolytic Uremic Syndrome (QTs than 450 msec in men and 470 msec in women), severe liver damage.
